![]() ![]() ![]() ![]() The resulting AIA interneuron responses have uniform magnitude and dynamics, suggesting that AIA activation is a stereotyped response to an integrated stimulus. AWA activates AIA through an electrical synapse, while the disinhibitory pathway acts through glutamatergic chemical synapses. We show that reliable AIA responses require the coincidence of two sensory inputs: activation of AWA olfactory neurons that are activated by attractive odors, and inhibition of one or more chemosensory neurons that are inhibited by attractive odors. AIA interneurons receive input from multiple chemosensory neurons that detect attractive odors. Here we define the logic of this transformation in a Caenorhabditis elegans integrating interneuron. The central nervous system transforms sensory information into representations that are salient to the animal. ![]()
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